Underlying Science agsdix-null Transplantation of nuclei from frog tumor (kidney carcinoma) cells to enucleated eggs result in normal organism development. agsdix-null Injection of myeloid leukaemic cells into embryos in utero produces healthy adult mice. agsdix-null Reprogramming metastatic melanoma cells injected into various embryonic microenvironments in zebrafish agsdix-null Normalization of tumor cells transplanted into immune privileged zone of the eye anterior chamber.